DESIGN AND EVALUATION OF BILAYER & TRILAYER TABLET COMBINATION OF ANTIRETROVIRAL DRUGS
AbstractA non-nucleoside reverse transcriptase inhibitor (NNRTI) is Nevirapine. Zidovudine and Lamivudine are antiretroviral medications that are members of the nucleoside analogue class. Combination of three drugs commonly used in the management of the Human Immunodeficiency Virus (HIV) infection. Nevirapine exhibits a decent initial release, while Zidovudine and Lamivudine demonstrate sustained release in the produced trilayer and bilayer tablets. The outcome demonstrates that the release profile is not affected by layer separation and is highly dependent on the drug to polymer ratio. The results show that the release can be effectively controlled for up to 12 hours using a 1:1 ratio of zidovudine and HPMC and a 1:1 ratio of lamivudine and ethyl cellulose. It is clear that formulation F1, out of all formulations, has the best sustained release, drug content, and highest regression values. Nevirapine fits best in first order release of Zidovudine in all of the F1–F6 formulations.
Article Information
29
2852-2857
651 KB
103
English
IJPSR
R. Natarajan * and R. Sambath Kumar
Department of Pharmaceutics & Research, The Erode College of Pharmacy, Erode, Tamil Nadu, India.
svcpnatarajan@gmail.com
18 April 2024
10 May 2024
24 May 2024
10.13040/IJPSR.0975-8232.15(9).2852-57
01 September 2024
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