DESIGN AND EVALUATION OF BILAYERED MUCOADHESIVE FILM OF CEFPODOXIME PROXETILAbstract
The objective of the present work was to formulate and evaluate a sustained release gastroretentive dosage form. A mucoadhesive bilayered film was prepared consisting of an Immediate Release (IR) and a Controlled Release (CR) layer. The film is folded into a Hard Gelatin Capsule which after administration into GIT unfolds and adheres to the GI mucosa. Cefpodoxime Proxetil is an antibiotic of BCS Class IV. Thus by retaining the drug in the gastric region its absorption is enhanced. Hence it is taken as the model drug. Different polymers like HPMC, EC and Carbopol were used for the film preparation and the mucoadhesive property was evaluated which showed that Presence of Carbopol increases the films mucoadhesive property. The in vitro drug release, bio-adhesion and mechanical property of the batches were evaluated to get the best batch. The optimization study of the film was carried out applying 32 factorial design. The final batch is subjected to In vivo gastroretention test on rabbits which showed a gastric adherence for 12hrs.
N. Banerjee and S.R. Singh
Dr. L.H. Hiranandani College of Pharmacy, Ulhasnagar-03, Mumbai, Maharashtra, India
29 October, 2013
16 December, 2013
09 March, 2014