DESIGN AND EVALUATION OF FAST DISSOLVING TABLET OF METOPROLOL TARTRATEAbstract
Many patients are express difficulty in swallowing tablets and hard gelatin capsules tending to non compliance and ineffective therapy. In the present work, fast dissolving tablets of metoprolol tartrate are formulated with a view to enhance the patient compliance. It is suited for tablets undergoing high first pass metabolism and is used for improving bioavailability with reducing dosing frequency to minimize side effect. Hence the main objective of the study was to formulate fast dissolving tablets of Metoprolol tartrate to achieve a better dissolution rate and further improving the bioavailability of the drug. These tablets prepared with a various concentration (4%, 5%, 6%w/w) of superdisintegrants such as crosscarmellose sodium (CCS), crosspovidone (CP) and pregelatinized starch (PGS) along with directly compressible mannitol to enhance mouth feel. The prepared tablet were evaluated for hardness, thickness, friability, weight variation, drug content uniformity, wetting time, water absorption ratio and in- vitro dispersion time, in- vitro disintegration and in- vitro dissolution profile are found satisfactory. Among the nine formulations, the formulation F9 containing pregelatinized starch emerged as the best formulation and showed maximum dissolution rate with 99.67% drug release in 8 minutes.
K. Senthil Kumar*, D. Dachinamoorthi, R. Saravanan and K. Ashok
Department of Pharmaceutics, QIS college of Pharmacy, Ongole -523272, Andhra Pradesh, India
30 April, 2011
13 May, 2011
25 July, 2011
01 August, 2011