DESIGN AND EVALUATION OF FAST DISSOLVING TABLETS OF CARVEDILOL USING SUBLIMATION TECHNIQUE
AbstractThe purpose of the study was to design and evaluate fast dissolving carvedilol tablets using β-Cyclodextrin and superdisintegrants adopting sublimation technique. Tablets were prepared by direct compression method. Tablets were evaluated for their physico chemical properties, wetting time, disintegration, in-vitro release and stability studies. SEM analysis was carried out to determine the surface characteristics of solid dispersions. Precompressional studies revealed good micromeritic properties of powder blend for direct compression. The hardness (3.9-4.3 kg/cm2), friability (0.35-0.51), drug content (96.58-99.43 %) and disintegration time (44.05-66.21 sec) of fast dissolving tablets were found uniform and reproducible. Dissolution of tablets was directly proportional to the superdisintegrants concentration. Selected tablet (F1) was found superior than any other formulations with respect to disintegration and dissolution time.
Article Information
34
3788-3795
759KB
1163
English
Ijpsr
Mohd Azharuddin*, Krishnananda Kamath and A.R. Shabaraya
Department of Pharmaceutics, Srinivas College of Pharmacy, Valachil, Mangalore, Karnataka, India
azhar.12345@rediffmail.com
05 June, 2012
25 July, 2012
20 September, 2012
http://dx.doi.org/10.13040/IJPSR.0975-8232.3(10).3788-95
01 October, 2012
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