DESIGN AND EVALUATION OF LOSARTAN POTASSIUM MATRIX TABLETS WITH NATURAL AND SYNTHETIC POLYMERSAbstract
The objective of the study was to formulate controlled release matrix tablets of losartan Potassium by using a combination of hydrophilic synthetic polymer like poly (ethylene oxides) and natural gums like xanthan gum, karaya gum and guar gum. A combination of synthetic hydrophobic polymers like methacrylates with synthetic hydrophilic polymer like poly (ethylene oxide) was also used in the preparation of matrix tablets and evaluated for their influence on controlled drug release. The matrix tablets were prepared by direct compression process and evaluated for hardness, weight variation, friability, swelling index and for in-vitro release of the drug. Preliminary evaluations showed that matrix tablets containing xanthan gum, guar gum and sodium alginate alone or in combination could not efficiently retard the drug release for prolonged period of time. The tablets containing combination of natural polymers and poly(ethylene oxides) and also methacrylates and poly(ethylene oxides) exhibited controlled release for a prolonged period of time. All the physical characteristics evaluated for the tablets were found to be within the acceptable limits.
R. L. C. Sasidhar*, S. Vidyadhara , N. Ramya Krishna and R. Nagaraju
Chebrolu Hanumaiah Institute of Pharmaceutical Sciences, Chowdavaram, Guntur- 522 006, Andhra Pradesh, India
20 November, 2011
23 February, 2012
26 February, 2012