DESIGN AND EVALUATION OF METHOTREXATE LOADED MULTILAYERED TABLET FORMULATION FOR TREATMENT OF COLON CANCERAbstract
The colon is a site where both local and systemic delivery of drugs can take place. Local delivery allows topical treatment of inflammatory bowel disease. However, treatment can be made effective if the drugs can be targeted directly into the colon, thereby reducing the systemic side effects. The aim of the present research work was to develop sustained release multi-layered formulation of Methotrexate, targeted to colon by using the combination of pH- dependent release, timed release and microbially triggered system. Multi-layered tablets were prepared by wet granulation technique method using starch paste as binder. Prepared formulations were subjected to various studies like hardness, friability, thickness, % drug content, weight variation etc. The influence of core tablet compositions, polymer combination ratios and coating levels on the in vitro release rate of Methotrexate from coated tablets was investigated. The results showed that less than 10% drug was released within %hrs (0.1 N HCl for2 hr and phosphate buffer pH 7.4 for 3hrs), and about 40% of the drug was released in the pH 6.8 phosphate buffer within 10.5 hr.
Jaideep Bhardwaj* and Sayantan Mukhopadhyay
Department of Pharmacy, GRD (PG) IMT, 214 Rajpur Rd., Dehradun -248009, Uttarakhand, India
01 November, 2013
26 December, 2013
24 March, 2014