DESIGN AND EVALUATION OF RIMONABANT LOADED SODIUM ALGINATE-GUAR-GUM MICROSPHERE FORMULATIONAbstract
Rimonabant is an anti-obesity drug which acts as Cannabinoid-1 receptor antagonist. Its main avenue of effect is reduction in appetite. The drug was formulated in the form of Sodium Alginate – Guar gum microspheres following ionotropic gelation method to reduce its dose related side effects. A detailed study of physical and chemical parameters including percentage drug loading and cumulative drug release was carried out and statistically evaluated. Each and every test on all batches was carried out in triplicate. After the experiment the microspheres showed good flow properties with drug entrapment efficiency recorded highest at 71.6%, drug loading results ranged from 12.91-18.20% and the yield percentage was recorded over 90% for all the formulations. The rate of drug release followed Higuchi matrix model equation.
B K Gupta*, Manas Chakraborty, R Debnath, Soumyadip Bose and S Nandy
Department of Pharmaceutical Technology, Jadavpur University, Kolkata (WB), India
15 April, 2010
16 June, 2010
01 August, 2010
15 August, 2010