DESIGN CHARACTERIZATION AND FORMULATION OF IN-SITU GELLING OPHTHAL-MIC DRUG DELIVERY SYSTEM CONTAINING PLANT DERIVED PHENOLS
AbstractThe objective of the present investigation was to formulate and evaluate ion-activated in-situ gel using the herbal drug catechin, a potential natural antioxidant for the treatment of glaucoma by lowering oxidative stress. A total of eight formulations were prepared and evaluated for parameters, namely physical appearance, gelling capacity, pH measurement, rheological studies, the effect of sterilization, drug content, in-vitro diffusion study, isotonicity evaluation, ocular irritancy studies, and stability test. Pre-formulation studies confirmed that the drug and polymer are compatible with each other. The XSG-2 formulation showed a maximum percentage drug release of 95.45%, which was considered as an optimized formulation and showed 5-6 folds increase in viscosity after gelation, which indicated good residence time further formulations were found to be non-irritating with no ocular toxicity and good stability. The current study results conclude that the developed catech in loaded ophthalmic in situ gel can be considered a better alternative approach to the conventional eye drop with an increase in precorneal residence time, reduced frequency of dosage, and patient compliance for the management of glaucoma.
Article Information
67
2458-2465
694
637
English
IJPSR
P. Akki *, F. S. Dasanakoppa and K. S. Akki
Department of Pharmaceutics, KLE College of Pharmacy, Vidyanagar Hubli, Karnataka, India.
pratiksha.akki8@gmail.com
04 February 2021
24 March 2021
15 March 2021
10.13040/IJPSR.0975-8232.12(4).2458-65
01 April 2021