DESIGN, DEVELOPMENT AND CHARACTERIZATION OF FAST DISINTEGRATING TABLET OF AMLODIPINE BESYLATE BY USING SUPERDISINTEGRANTS PLANTAGO OVATA AND LOCUST BEAN GUMAbstract
The objective of the present study was to develop and characterize the fast disintegrating tablets, which rapidly disintegrates in the sublingual area without the need of water or with a little amount of water. Amlodipine besylate is a calcium channel blocker (long-acting) basically used in the treatment of angina and hypertension for immediate relief in life-threatening conditions. In this work, we prepared the fast disintegrating tablet of Amlodipine besylate for the increasing rate of dissolution using two different classes of super-disintegrating agents naturals are (Locust bean gum; Plantago ovata) and synthetic are (Croscarmellose sodium, Crospovidone). The method of preparation was direct compression. The pre-formulation studies were also performed. The tablets were prepared and evaluated according to the parameters in the pharmacopeia. Results revealed that fast disintegrating tablets prepared with Locust bean have the highest drug release (in-vitro) of 98% within 30 min. The use of Locust bean as super disintegrant has majorly promoted the rapid release of the active drug. This study gives knowledge about the pivotal fundaments related to the formulation of Amlodipine besylate.
H. Singh *, A. Majumdar, N. Malviya and S. Saxena
Smriti College of Pharmaceutical Education, Indore, Madhya Pradesh, India.
28 November 2019
12 April 2020
15 April 2020
01 December 2020