DESIGN, DEVELOPMENT AND EVALUATION OF MATRIX TABLET CONTAINING INDIGENOUS MEDICINAL PLANTSAbstract
A Sustained release tablet formulation should ideally have a proper release profile that is usually encountered in manufacturing. The objective of the present investigation was to develop the sustained release matrix tablet of Boswellia serrata, Moringa oleifera and Vitex negundo using the combination of hydrophilic and hydrophobic polymers.Tablet formulations were developed using wet granulation method. Ethanolic extracts of Boswellia serrata, Moringa oleifera and Vitex negundo were used. Addition of different diluents like talc , magnesium stearate and microcrystalline cellulose were used for improving flow ability and compressibility. The tablets were subjected to physicochemical characterization, in vitro drug release and stability studies. The physicochemical properties were found within limits. The % drug release after 12 hours for formulation F-1, F-2, F-3 was found to be 97.32, 90.12, and 73.85 respectively. The presence of Ethyl cellulose as well as HPMC as the total matrix material significantly influenced the release rate of the drug. Based on dissolution studies all the formulations showed sustained release of drugs from the formulations.
Trapti Rastogi* and Dr. S. S. Khadabadi
Government College of Pharmacy, Kathora Naka Road, Amravati-444604, Maharashtra, India
24 June, 2011
25 August, 2011
14 October, 2011
01 November, 2011