DESIGN, DEVELOPMENT AND OPTIMIZATION OF VALSARTAN LIQUISOLID TABLETS USING BOX-BEHNKEN DESIGNAbstract
The aim of the present study was to investigate the applicability of liquisolid technique in improving the dissolution properties of Valsartan in a solid dosage form. This study was designed to optimize and evaluate the effects of different formulation variables: amount of liquid vehicle (X1), ratio of carrier to coating material(X2) and amount of magnesium oxide(X3) on angle of repose (Y1), hardness(Y2) and in-vitro release(Y3) of formulation using three level three factor Box-Behnken statistical design. The non-linear quadratic model generated by the design is of the form: Y = A0 + A1X1 + A2X2 + A3X3 + A4X1X2 + A5X2X3 + A6X1X3 + A7X12 + A8X22 +A9X32 + E, where Y is the measured response associated with each factor level combination. Contour and response surface plots were depicted based on the equation given by the model. The optimization procedure generated the maximum overall desirability value. The optimized formula yields observed values close to the predicted values. Furthermore, the commonly used carrier and coating materials in liquisolid systems Avicel® and Aerosil® were replaced by Neusilin®, an amorphous magnesium aluminometasilicate with an extremely high specific surface area of 339 m2/g to improve the efficiency of liquisolid approach.
C.V. Shah*, H.K. Patel, V.H. Shah and U.M. Upadhyay
Deparrment of Pharmaceutics, Sigma institute of Pharmacy, Baroda, Gujarat, India
20 April, 2012
22 June, 2012
27 July, 2012
01 August, 2012