DESIGN, DEVELOPMENT AND SYNTHESIS OF NOVEL CHIRAL DERIVED MOLECULES, POTENTIALLY ACT AS RNA POLYMERASE NSP-12 AND NSP-6/10 COMPLEX INHIBITORS AGAINST COVID-19Abstract
Novel Di and Tridentate chiral molecules and its analogues were designed and synthesized in that the chiral amino ester and 2-amino-3, 5-dibromobenzaldhehyde were condensed. Further, it has coupled with Cassic acid to form desired active molecules. The developed compounds are evaluated for molecular docking to check potency and may represent potential drug candidate inhibitors of RNA dependent RNA polymerase of Covid-19, compare to Remdesivir and Hydroxychloroquine. The present work is to identify and investigating the potential drug out of eight compounds that may be used to inhibit RNA-dependent RNA polymerase non-structural proteins complex of Covid-19 to prevent the replication of viral genome in host cells. The compounds BNT-202006, BNT-202008 & BNT-202009 showed and exhibited minimum binding energy when it bound with protein targets when compared with Remdesivir and Hydroxychloroquine as standard drug.
M. Balaachari *, M. Menaga and S. P. Sri
Bioneemtec India Private Ltd, Women’s Biotech Park, Siruseri, Tamil Nadu, India.
23 June 2020
15 December 2020
16 December 2020
01 January 2021