DESIGN, FORMULATION AND EVALUATION OF BITTER LEAF TABLETSAbstract
Vernonia amygdalina, commonly called bitter leaf, is a perennial shrub that belongs to the family Asteraceae and grows throughout tropical Africa. Traditional medicine practitioners use the plant as in treatment of several disease conditions especially diabetes mellitus. In this research, the feasibility of tableting Vernonia amygdalina leaf was examined using three binders. Tableting of the leaf powder was done using wet granulation method. Various physicochemical parameters (angle of repose, bulk density, tapped density, Hausner’s ratio, Carr’s index, ash value etc.) were determined and found to be within normal limits. The strength of the tablets was assessed by crushing strength and friability of the tablets while the release properties were determined using disintegration and dissolution times. The result showed that the feasibility of tableting the leaves of Vernonia amygdalina is high, possible and promising and that gelatin is a better binder compared to maize starch and microcrystalline cellulose for tableting the leaf of Vernonia amygdalina.
J. Muazu*, A. Abdulwoliyu and G.T. Mohammed
Department of Pharmaceutics and Pharmaceutical Microbiology, University of Maiduguri, Maiduguri, Nigeria
07 January, 2013
21 March, 2013
30 April, 2013
01 May, 2013