DESIGN IN-SILICO MULTIPATHOGENIC VACCINE OF DENGUE AND ZIKA VIRUSES USING ENVELOPE PROTEINAbstract
The Flaviviridae family of viruses includes the dengue virus (DENV) and the Zika virus (ZIKV). Which have already caused outbreaks and epidemics in a number of countries in the entire world. Dengue fever and Zika fever are two and among the most widely disseminated mosquito-borne viral illnesses in the world both of these diseases have the potential to erupt in many places of the world at the same time, and they can be lethal as well as life-threatening. Unfortunately, there isn’t a vaccine that works well enough to combat these viruses. As a result, we used an immunoinformatics method to build a multivalent and multipathogenic epitope-based vaccination that can combat both DENV and ZIKV infections at the same time in this study. ZIKV epitope QPENLEYRI and DENV epitope NKPTLDFEL docking scores of -346.10 and -379.80 were designed for a multivalent and multipathogenic vaccine that contained non-allergenic but also highly antigenic T-cell (100 percent conserved) from DENV and ZIKV serotypes.
Neeraj Kumar Dixit
Department of Biotechnology, Saroj Institute of Technology & Management, Lucknow, Utter Pradesh, India.
20 January 2022
05 April 2022
26 April 2022
01 September 2022