DESIGN OF CORE COMPRESSED TABLETS OF AZITHROMYCIN AND BROMHEXINE HYDROCHLORIDE AS DUAL RELEASE SYSTEM

Bromhexine hydrochloride, mucolytic agent used in the treatment of respiratory disorders. Azithromycin is use in wide variety of bacterial infections. The aim of this present work is to formulate dual drug delivery system containing azithromycin as immediate release and bromhexine hydrochloride as sustained release action. The sustained release part as core tablet of bromhexine prepared because of the frequent daily dosing is required for therapy. The floating formulation of core tablet was prepared because it dissolved in the pH range of 1 to 4. The core tablets of bromhexine hydrochloride were prepared by wet granulation technique. The prepared core tablets were evaluated for different parameters for selection of formula for floating the tablets. The core compressed tablets were evaluated for quick release of coat layer containing disintegrants. The various formulations of core tablets were prepared using HPMC K4M and K15M in different concentration. The prepared tablets were evaluated for physical parameters, disintegration time, floating lag time and drug release study. All the batches show around 70 sec disintegration time, 90 sec floating lag time and drug release up to 12 hrs. In batch B5 containing 30% of HPMC K15M found adequate drug release of bromhexine hydrochloride up to 12 hrs