DESIGN, OPTIMIZATION AND EVALUATION OF MUCOADHESIVE BUCCAL TABLET OF VALSARTANAbstract
The main aim of this work was to formulate and study mucoadhesive buccal tablets of valsartan using various suitable bioadhesive polymers such as CP 934 and Xanthan gum. Nine formulations of valsartan were prepared by the direct compression method. The prepared tablets were characterized by swelling studies, % matrix erosion, surface pH, bioadhesive properties, in-vitro drug dissolution and in-vitro diffusion studies. It was found that CP 934 increases the swelling index also increased. The surface pH of all formulations was found to be satisfactory, and values were in between the range of 5-7 pH, hence no irritation to the buccal cavity is assumed. Tablets containing CP: Xanthan gum in the ratio 3:1 has shown the maximum percentage of in-vitro drug release through the buccal mucosa. The drug release was found to be zero-order release. The formulation F3 was considered as the optimized formulation based on satisfactory bioadhesive strength, in-vitro dissolution drug release of 96.72 ± 0.43%, for 12 h.
D. M. Shinkar, T. A. Shaikh * and R. B. Saudagar
Department of Pharmaceutics, Kalyani Charitable Trust's, Ravindra Gambhirrao Sapkal College of Pharmacy, Anjaneri, Nashik, Maharashtra, India.
22 June 2019
24 November 2019
08 February 2020
01 May 2020