DESIGN, SYNTHESIS AND ANTICANCER ACTIVITIES OF NOVEL UNSATURATED FATTY ACID-BASED b-HYDROXY 1,2,3-TRIAZOLESAbstract
A series of novel unsaturated fatty acid based b-hydroxy 1,2,3-triazole hybrids were designed and synthesised in excellent yields by esterification, epoxidation of oleic, ricinoleic and 10-undecenoic acids followed by azidolysis and “click” reaction with different alkynes. All the b-hydroxy 1,2,3-triazole hybrids were characterised by ESI-MS, IR and NMR spectra as well as HRMS analysis and were screened in vitro for their anticancer activity against selected four human cancer cell lines (DU-145, HeLa, MCF-7 and A549) in comparison with doxorubicin, a standard anticancer drug. Among all the triazoles, methyl oleate with-CH2OH as 1,2,3-triazole side chain (1dii) exhibited good anti cancer activity against DU-145, HeLa, MCF-7 and A549 human cancer cell lines with IC50 values 10.73, 13.61, 11.93, and 16.54 μM respectively.
V. Manneganti, L. Anu Prabhavathi Devi Bethala *, B. N. Prasad Rachapudi , A. Singh, R. Ummanni
Centre for Lipid Research, Indian Institute of Chemical Technology, Hyderabad , AP, India
18 August, 2014
24 November, 2014
19 December, 2014
01 April, 2015