DESIGN, SYNTHESIS AND CYTOTOXIC ACTIVITY OF SOME NOVEL FLAVONES
AbstractA series of flavones (5-15) weresynthesized from resorcinolvia Baker-Venkataraman transformation, characterized and evaluated for their cytotoxicity against human cervical cell line (HeLa) by MTT assay method. The result of preliminary MTT cytotoxicity studies shown that the compounds 5, 9 and 10 were found to be most potent against HeLa cells; IC50 values were of 0.22, 0.88 and 1.26 µM respectively.
Article Information
32
523-527
606KB
1012
English
IJP
Palani Venkatesh*, Govindaraman Prakash and Parasuraman Pavadai
Department of Medicinal Chemistry, Mother Theresa post graduate and Research Institute of Health Sciences, Pondicherry University, Puducherry-605006, India
04 October, 2011
04 October, 2011
21 January, 2012
29 January, 2012
http://dx.doi.org/10.13040/IJPSR.0975-8232.3(2).501-08 http://dx.doi.org/10.13040/IJPSR.0975-8232.3(2).523-27
01 February, 2012
Download