DESIGN, SYNTHESIS AND EVALUATION OF SOME NOVEL DIHYDROPYRIMIDINE DERIVATIVES AS POSSIBLE ANTIMICROBIAL AGENTSAbstract
Pyrimidine is a six membered cyclic compound containing 4 carbon and 2 nitrogen atoms and is pharmacologically inactive but its synthetic derivatives possess an important role in modern medicine. Pyrimidines and their derivatives are considered to be important for drugs and agricultural chemicals. Pyrimidine derivatives possess several interesting biological activities such as antimicrobial, antitumor and antihypertensive activities. Many pyrimidine derivatives are used for thyroid drugs and leukemia. The biological significance of the pyrimidine derivatives has promoted us to synthesize some new substituted dihydropyrimidines, and evaluate them for their anti-microbial activity. The titled compounds were identified and characterized by IR and 1HNMR analysis.
K.P. Beena*and T. Akelesh
Assistant Professor, Department of Pharmaceutical Chemistry, KMCH College of Pharmacy, Kovai Estate, Kalapatti Road, Coimbatore-641048, Tamil Nadu, India
06 September, 2012
16 October, 2012
28 November, 2012
01 December, 2012