DESIGN, SYNTHESIS AND MOLECULAR DOCKING STUDIES ON NOVEL CINNOLINE DERIVATIVES AS POTENTIAL ANTITUBERCULOSIS AGENTSAbstract
The emerging need for the multidrug regimen of M. tuberculosis strains urged us to synthesize novice and potent anti-tubercular medicaments. Our interest in this work had afforded a series of novice cinnolines as a new structural category of antituberculosis agents. All 14 compounds were synthesized using the appropriate scheme, two-step reactions with the high yielding product. The newly synthesized cinnoline Compounds were examined for their in-vitro drug-sensitive M. tuberculosis H37Hv strain. To date, evaluation of anti-tubercular activity various drugs in the multidrug regimen is on going out of which INH highly effective component drug and is advised by WHO. Some of the derivatives were considered to be promising inhibitors of M. tuberculosis. For example, the most active compound (CN-14) exhibited 12.5 μg/ml inhibitions against drug-sensitive M. tuberculosis H37Rv strain.
M. P. Evangelin *, P. P. Kumar and K. Balamurugan
Department of Pharmacy, Annamalai University, Chidambaram, Tamil Nadu, India.
10 January 2020
03 March 2020
19 March 2020
01 April 2020