DETECTION OF ACTIVE CONSTITUENTS FROM THE LEAF EXTRACT OF LANNEA COROMANDELICA BY GC-MS TESTING AND ASSESSMENT OF ITS PHARMACOLOGICAL ACTIVITYAbstract
Lannea coromandelica (Anacardiaceae) is a tropical tree commonly called as Indian ash tree. Its various parts is said to possess medicinal property and used in Ayurveda and other ancient system of medicine for the treatment of various ailments including treatment of inflammation, gout, cholera, leprosy, vaginal troubles etc. Its Pharmacological study revealed anti-inflammatory, antimicrobial, hypotensive, anticancerous activities. Leaves of Lannea coromandelica were collected from Azhagar malai, Madurai. The sample specimen of Lannea coromandelica was identified and authenticated by Dr. Jaya Raman, Taxonomist, Chennai. The present work was carried out to identify some of the phytocomponents present in the ethanolic leaf extract of the L. coromandelica by GC-MS technique, to ascertain the medicinal properties of the plant and also to assess its anti-oxidant and anti-arthritic potential of ethanolic leaf extract of Lannea coromandelica. The results revealed that ethanolic extract is mainly composed of oxygenated hydrocarbons and predominantly phenolic hydrocarbons. These different active phytochemicals may be responsible for wide range of activities, which may help in the protection against incurable diseases. The future in vivo investigation should be carried out to confirm the activity in animal models.
Deepa Selvaraj *, Anusha Kotapadu, Bandla Sampurna, Balaji P, Aleena Ann Abraham, Sathesh Kumar Kesavan and Chitra Krishnan
Faculty of Pharmacy, Sri Ramachandra University, Porur, Chennai-600116, India
15 July, 2014
21 October, 2014
19 January, 2015
01 March, 2015