DETERMINATION OF RIZATRIPTAN IN BULK AND ITS TABLET DOSAGE FORMS BY UV SPECTROSCOPIC METHOD.Abstract
Rizatriptan is a selective 5-HT1B/1D agonist which is used in the treatment of migraine headaches. Zero order spectroscopic method has been developed for the determination of rizatriptan. Rizatriptan in its 0.1 N HCl solutions was determined at the wavelength ranges of 220–400 nm by the spectroscopic method. Rizatriptan showed an absorption peak at 226 nm. Linearity ranges were found as 1-5 µg/ml. for the zero order UV spectroscopic method. Limit of quantitation was determined as 0.0944 µg/ml whereas limit of detection was calculated as 0.0311 µg/ml for the same measurements, respectively. No interference was found from tablet excipients at the selected wavelengths and assay conditions. Developed method was found to be validated and showed good precision and reproducibility. Proposed method was successfully applied to the assay of rizatriptan in pure and tablet dosage forms and assessed as to be rapid, sensitive, accurate and relatively inexpensive.
Devprakash, G. P. Senthilkumar, Prithviraj S. Yadav* and Mani T. Tamizh
Department of Pharmaceutical Chemistry, Bharathi College of Pharmacy, Bharathi Nagara, Mandya (District), Karnataka, India
24 March, 2011
23 April, 2011
28 July, 2011
01 August, 2011