DETERMINATION OF TOLTERODINE TARTRATE IN PHARMACEUTICAL PREPARATIONS USING EOSIN, APPLICATION TO STABILITY STUDYAbstract
Spectrophotometric method has been developed for the determination of Tolterodine tartrate (TOL) which is based on formation of a binary complex between TOL and eosin at 545 nm using acetate buffer at pH 3.8.The absorbance-concentration plot is rectilinear over the range (1-10μg/ml) with LOD of 0.1μg/ml and LOQ of 0.31μg/ml. The proposed method was successfully applied to the analysis of commercial tablets containing the drug and the results were in good agreement with those obtained with the reference method. The method was also utilized to investigate the kinetics of alkaline, acid and oxidative degradation of the drug .It was found to be stable upon acidic and alkaline degradation and only undergo oxidative degradation using 33.3%H2O2. The apparent first order rate constant and t1/2 of the oxidative degradation reaction were calculated.
M. I. Walash, F. Belal, N. El-Enany* and H. Elmansi
Department of Analytical Chemistry, Faculty of Pharmacy, University of Mansoura, 35516, Mansoura, Egypt
04 July, 2011
30 September, 2011
27 October, 2011
01 November, 2011