DEVELOPMENT AND CHARACTERIZATION OF TENOXICAM ENCAPSULATED NIOSOMES FOR ENHANCED TRANSDERMAL DELIVERYAbstract
Objective: The aim of this current research is to study a novel carrier, niosome, for its enhanced transdermal delivery of tenoxicam. Methods: Niosomes are self assembled vesicles composed primarily of synthetic surfactants, cholesterol & edge activator (surfactant). Niosomes were prepared by Organic solvent injection technique and characterized by particle size, entrapment efficiency, transmission electron microscopy (TEM), ex-vivo skin corrosive test, in-vitro dissolution, ex-vivo permeation studies and in-vivo study. Results: Vesicle size and % EE of the optimized niosomal formulation was found to be 79.46 ± 55 nm and 88.8 ± 4.5% respectively. Zeta potential of the optimized niosomal formulation was found to be -39.6 ± 7.43 mv. The ex-vivo study showed transdermal flux of niosomal gel to be 43.09± 0.106µg/cm2/h which was 2.9 fold higher than that obtained after application of plain drug gel whose flux was 15.05±0.09 µg/cm2/h). Conclusions: Data obtained from this experimental work concludes niosomal formulation is safe, very effective and promising drug carrier for transdermal delivery of drug.
J. Shaji* and A. Shah
Department of Pharmaceutics, Prin. K. M. Kundnani College of Pharmacy, Cuffe Parade, Mumbai- 400005, Maharashtra, India.
23 June, 2015
22 August, 2015
19 October, 2015
01 January, 2016