DEVELOPMENT AND EVALUATION OF A DIRECTLY COMPRESSIBLE CO-PROCESSED MULTIFUNCTION SUSTAINED RELEASE AGENT FOR ISOSORBIDE MONONITRATE SUSTAINED RELEASE TABLETS
AbstractDirectly compressible co-processed sustained release multifunction agent [DCCSRA] comprising povidone and glyceryl behenate in the ratio of 1:1, 1:2 and 1:3 were prepared and evaluated for formulation of sustained release tablets of isosorbide mononitrate. The DCCSRA exhibited good flow and compressibility. The DCCSRA, prepared by hot melting method and co-precipitation method served as a retardant, binder and lubricant in isosorbide mononitrate sustained release tablets. The DCCSRA may be used for manufacturing of isosorbide mononitrate sustained release tablets.
Article Information
14
103-113
625 kB
1131
English
IJPSR
J. Ayyappan*, P. Umapathi and Darlin Quine
Department of Research and Development, Micro Labs Ltd, 67/68-A, Third Phase, Peenya Industrial Area, Bangalore, Karnataka, India
23 May, 2010
19 August, 2010
14 September, 2010
http://dx.doi.org/10.13040/IJPSR.0975-8232.1(10).103-13
01 October, 2010
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