DEVELOPMENT AND EVALUATION OF FAST-DISSOLVING TABLETS OF AN ANTI-GOUT DRUG BY SUBLIMATION METHODAbstract
The purpose of the current research was to formulate and evaluate patient-friendly allopurinol solid dispersion based fast-dissolving tablets using a sublimation technique in order to accomplish rapid drug dissolution. In the present study, an effort was made to fasten the release of allopurinol from oral tablet dosage form by the conversion of the drug into solid dispersion form followed by further incorporation of allopurinol solid dispersions with superdisintegrants and camphor/ammonium bicarbonate as the subliming agents. The prepared fast-dissolving tablets of allopurinol solid dispersion were analyzed for pre-compression and post-compression parameters. Based on the results obtained for in-vitro drug release studies, it was observed that the formulation F8 showed a fast release profile of about 99.51% in 30 min and a disintegration time 40 sec in comparison with other formulations. The initial dissolution rate was 34.25% / 10 min for the best formulation, F8. FT-IR studies disclosed that there were no interactions between drugs and excipients. The current investigation revealed the potential for the rapid dissolution of allopurinol solid dispersion fast-dissolving tablets prepared by the sublimation method.
SK. Arifa Begum *, G. Joshua, K. Bharath and B. Akash
Department of Pharmaceutics & Biotechnology, KVSR Siddhartha College of Pharmaceutical Sciences, Siddhartha Nagar, Vijayawada, Andhra Pradesh, India.
21 August 2021
02 August 2022
21 August 2022
01 September 2022