DEVELOPMENT AND EVALUATION OF HERBO SYNTHETICGEL: A NOVEL TREATMENT FOR PSORIASISAbstract
Background: Psoriasis is an immune-mediated inflammatory disease characterized by excessive growth and abnormal differentiation of keratinocytes. Objective: In the present research work, an attempt has been made to formulate and evaluate gel containing cyclosporine, aloe vera and tree tea oil. Methods: The gel was prepared by a conventional method and evaluated for various parameters viz., physical appearance, pH, drug content, viscosity, spreadability and in-vitro diffusion studies, In-vitro skin retention studies and stability studies. The prepared optimized gel was further compared with marketed formulation; all the formulations were good in appearance and had good homogeneity. Results: The optimized gel is shown spreadability co-efficient is 5.8 g cm/sec. The gel has shown 95 ± 0.32% releases in 6 h when evaluated for in-vitro diffusion studies. The biological evaluation of the optimized gel has shown 47.98 % drug activity, indicating good efficacy of the formulation against psoriasis. Conclusion: In conclusion, the prepared optimized gel has shown good spreading co-efficient and stability and can be effective for psoriasis as compared to available gel in the market.
Vinay Pandit * , Anurag Kumar, Tarun Kumar Sharma, CPS Verma and Shiv Kumar Kushawaha
Department of Pharmaceutics, Kathog, Distt, Kangra, Himachal Pradesh, India.
03 August 2020
27 July 2021
28 July 2021
01 September 2021