DEVELOPMENT AND EVALUATION OF ORAL COLON TARGETED KETOROLAC TROMETHAMINE CAPSULEAbstract
The present endeavour was directed towards fabrication of the novel colon drug delivery system of ketorolac tromethamine capsule. Hard gelatin Capsules were fabricated using combination of both microflora activated natural polysaccharide (guar gum) and pH-dependent polymer (cellulose acetate phthalate). In vitro drug release studies revealed that Ketorolac tromethamine granules bearing hard gelatin capsules coated with cellulose acetate phthalate released drug only at higher pH (6.8 PBS), in vitro drug release studies showed that capsules were retained in stomach pH (1.2 N HCl) with-out any drug release, whereas minimal amount of drug release in small intestine pH (7.4 PBS) and almost drug release showed in the colonic pH (6.8 PBS). The rate of drug release was observed fast with caecal content (4% w/w rat caecal) than the control medium. Hence 50% guar gum containing coated capsules may be potentially useful for delivery of ketorolac tromethamine for colon. The drug release follows case ІІ (non- fickian) diffusion control mechanism.
Manish Neekhra *, Sarika Shrivastav, Sarvesh Sharma, K I Molvi and Vimal Kumar
Department of Pharmaceutics, Laxmi Narain College of Pharmacy, Bhopal, (MP), India
13 February, 2010
18 April, 2010
20 April, 2010
01 May, 2010