DEVELOPMENT AND EVALUATION OF PUSH-PULL BASED OSMOTIC DELIVERY SYSTEM FOR ROPINIROLE
AbstractRopinirole hydrochloride is indicated in Parkinson’s disease and Restless leg syndrome. In advanced Parkinson’s disease the usual dose of Ropinirole hydrochloride is 0.25 to 5 mg three to four times a day. Hence, an attempt was made to develop a once-a-day controlled release Osmotic drug delivery system. This may offer significant patient benefits by providing enhanced efficacy and reduced side effects and may also reduce the number of daily doses compared to conventional therapies. An oral push-pull system that can deliver Ropinirole hydrochloride for extended period of time has been developed and characterized. A bilayer osmotic drug delivery system was developed using drilling technique. The push layer swells releasing the drug at a controlled rate. An optimized system was selected to study the effect of pH of dissolution medium and the effect of agitation intensity. The drug release was found to follow zero order kinetics. The developed push-pull osmotic system showed the desired once-a-day release kinetic.
Article Information
39
3211-3218
861KB
1270
English
IJPSR
Adarsh Shah*, Viral Shah and U.M. Upadhyay
Sigma Institute of Pharmacy, Vadodara, Gujarat, India
adarsh1912@yahoo.com
11 May, 2012
14 June, 2012
22 August, 2012
http://dx.doi.org/10.13040/IJPSR.0975-8232.3(9).3211-18
01 September, 2012
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