DEVELOPMENT AND EVALUATION OF TASTE MASKED ORODISPERSIBLE TABLET OF OFLOXACINAbstract
Ofloxacin is an antibacterial agent used to treat infections. It is extremely bitter in taste and taste should be masked to formulate it in a palatable form. The purpose of present research work was to formulate tasteless complexes of ofloxacin with indion 204 ion exchange resin. The drug loading onto ion-exchange resin was optimized for mixing time, activation, effect of pH, mode of mixing, ratio of drug: resin and temperature. The resinate was evaluated for taste masking and in vitro drug release. DSC analysis study supported complex formation. ofloxacin- indion 204 complex of ratio 1:1.5 was developed into orodispersible tablet using different superdisintegrants with varying concentration and was evaluated for weight variation, hardness, friability, wetting time, water absorption ratio, content uniformity, disintegration time and dissolution and was found superior over conventional formulation. The F5 batch with disintegration time 19.33 Sec ±3.78 and dissolution within 45 minutes 89.642±2.20 was selected as optimized formulation. By an appropriate selection and combination of excipients, it was possible to obtain orodispersible and taste masked tablets. Batch F5 Contains, Ofloxacin: Indion-204 complex (1:1.5 Ratio, Sodium starch Glycolate, Crosspovidone, Crosscarmellose sodium, NaHCO3, Citric acid, Mannitol, Talc.
S.P. Dhamane*, M.P. Wagh , G.P. Asnani , A. S. Kulkarni , B. S. Patil and A.S. Gadekar
JSPM’s Jayawantrao Sawant College of Pharmacy & Research, Hadapsar, Pune, Maharashtra, India
29 November, 2012
21 January, 2013
19 February, 2013
01 March, 2013