DEVELOPMENT AND EVALUATION OF VERAPAMIL HYDROCHLORIDE XANTHAN GUM MICROCAPSULES AS CONTROLLED DRUG DELIVERY SYSTEMAbstract
In the present study, the microspheres containing Verapamil hydrochloride xanthan complexes encoated with ethyl cellulose by emulsion solvent evaporation method. DSC shown absence of any new endothermic peak, disappearance of no shift of endothermic peak confirmed that there is no any interaction between drug, excipients and the drug was thermally stable. Drug polymer ratio was altered while the other formulation parameters were kept constant and percentage yield, incorporation efficiency, particle size and distribution of the microcapsules were analyzed. The microcapsules studied for effects of the increase polymer ratio in formulation. The dispersed phase viscosities were evaluated by comparing with variations in particle size and distribution of the microcapsules and the effect of the variation in polymer ratio on drug dissolution was evaluated. The percentage drug released at the end of 12th h (VXM2) was found be 95.95%. respectively. The mechanism of drug release may also be dissolution and diffusion mechanism controlled released formulation. The stability of Verapamil hydrochloride loaded microcapsules (VXM2) formulation was stored at 40oC±2oC/75% RH ±5% RH for three months.
B.E. Wanjari* and N.J. Gaikwad
Manoharbhai Patel Institute of Pharmacy, Kudwa, Gondia- 441 614, Maharashtra, India
16 May, 2012
13 June, 2012
25 August, 2012
01 September, 2012