DEVELOPMENT AND IN-VITRO EVALUATION OF FLOATING MICROSPHERES OF 5-FLUOROURACILAbstract
Objective of the present study was to prepare and evaluate floating Microspheres using different ratio of ethylcellulose to control the release rate of 5-Fluorouracil (5-Fu) which was taken as a model drug. The microspheres were prepared by the modified emulsion solvent diffusion technique using different ratio of ethanol (ETN) and acetone (ACTN) as solvent system. To study the morphology of microspheres optical and scanning electron microscopy was used. The maximum yield of microspheres was up to 84.85±3.97%. Microspheres showed passable flow properties. On the basis of results of optical microscopy particle size range was found to be ranging from 130.90±12.10 to 175.43±12.32 mm. SEM photographs confirmed their spherical size, perforated smooth surface and a hollow cavity in them. Microspheres exhibited floating properties for more than 10 hours. In vitro drug release studies were performed in 0.1N HCl with 0.1 % SLS. Different drug release kinetics models were applied for selected batches.
P. Bhardwaj*, R. Singh and A. Swarup
Adarsh Vijendra Institute of Pharmaceutical Sciences, Babu Vijendra Marg, Gangoh, Saharanpur- 247 341, Uttar Pradesh, India
17 November, 2011
20 February, 2012
25 February, 2012