DEVELOPMENT AND VALIDATION OF SPECTROPHOTOMETRIC METHOD FOR DETERMINATION OF RISPERIDONE BY MBTHAbstract
A simple and sensitive visible spectrophotometric method is described for the assay of risperidone (RSP) in pure and solid dosage forms. The method involves oxidative coupling of risperidone with MBTH in presence of ferric chloride dissolved in HCl and apple green chromogen is formed and exhibits absorption maxima at 595.8nm. Regression analysis of Beer-Lambert plots showed good correlation in the concentration ranges (10-80) μg/mL. Regression coefficient was found to be 0.992. The proposed method is applied to commercial available tablets and the results are statistically evaluated and validated by recovery studies. The proposed methods have been successfully applied to the analysis of the bulk drug and its tablet dosage form. The methods have been statistically evaluated and were found to be precise and accurate.
S. Archana*, Y. Naga Prasanna, P. Pavitra, D. Santhi Krupa, M. Hema Sri
Research Lab., Aditya Institute of Pharmaceutical Sciences & Research, ADB Road, surampalem, Kakinada, Andhra Pradesh, India
27 November, 2012
22 January, 2013
23 February, 2013
01 March, 2013