DEVELOPMENT AND VALIDATION OF SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS ESTIMATION OF CINNARIZINE AND DOMPERIDONE MALEATE IN PURE AND TABLET DOSAGE FORMAbstract
The method for the simultaneous estimation of Cinnarizine and Domperidone maleate from tablet dosage form has been developed, based on simultaneous equation method at two selected wavelength 254nm and 284nm respectively, and also absorbance ratio method at two selected wavelengths 274.0nm (Iso-absorptive point) and 254.0nm (λmax of cinnarizine). The linearity was obtained in the concentration range of 5-20μg/ml and 5-20μg/ml for cinnarizine and Domperidone maleate respectively. These methods are simple, accurate and results of analysis have been validated statistically and by recovery studies.
K.N. Tarkase*, M.K. Tarkase, M.D. Dokhe and V.S. Wagh
Department Of Quality Assurance Technique, Padmashree Dr. Vithalrao Vikhe Patil Foundations, College of Pharmacy, Viladghat, Ahmednagar- 414111, Maharashtra, India
19 April, 2012
16 May, 2012
27 July, 2012
01 August, 2012