DEVELOPMENT AND VALIDATION OF SPECTROPHOTOMETRIC METHOD FOR THE ESTIMATION OF FLUCLOXACILLINAbstract
A new, simple, sensitive and reproducible spectrophotometric method has been developed for the estimation of Flucloxacillin in pure form. Method involves the determination of Flucloxacillin by dissolving in water and followed by measuring the absorbance at 273 nm. The linearity was obtained in the concentration range of 100-300 µg /ml. The suitability of method for quantitative analysis of Flucloxacillin was proved by validation. This method was extended to tablet formulation and there was no interference from excipients and diluents. This method has been statistically validated and is found to be precise and accurate.
Vipin Prakash*, Sharif Niroush Konari , Gerad Suresh
Assistant Professor, JDT Islam College of Pharmacy, Calicut -673 012, kerala, India
23 February, 2012
17 March, 2012
24 May, 2012
01 June, 2012