DEVELOPMENT AND VALIDATION OF TWO SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS ESTIMATION OF METRONIDAZOLE AND OFLOXACIN IN SUSPENSION
AbstractTwo simple, sensitive, rapid, accurate and economical methods were developed for the estimation of Metronidazole and Ofloxacin in two component liquid dosage form. First method is based on the simultaneous equation and second method is based on Q-analysis (absorbance ratio method). Metronidazole has absorbance maxima at 318.0 nm and Ofloxacin has absorbance maxima at 294 nm in acetonitrile and diluent(70:30) solvent PH of 9.89. The linearity was obtained in the concentration range of 5-30 μg/ml for Metronidazole and 3-18 µg/ml for Ofloxacin. In the first method, the concentrations of the drugs were determined by using simultaneous equations and in second method, the concentration of the drugs were determined by using ratio of absorbances at isoabsorptive point and at the λ-max of one of the drug. The results of analysis have been validated statistically and by recovery studies
Article Information
25
3202-3206
499
1231
English
Ijpsr
Nirav B Patel* Alpesh C. Aravdiya and Hemant T. Desai
Nirlife Healthcare (Healthcare Division of Nirma), Sachana- 382150, Ahmadabad, Gujarat, India
14 August, 2011
08 November, 2011
28 November, 2011
http://dx.doi.org/10.13040/IJPSR.0975-8232.2(12).3202-06
01 December, 2011
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