DEVELOPMENT, CHARACTERIZATION AND IN-VITRO ANTIFUNGAL EVALUATION OF PLANTEROSOMAL GEL OF GANODERMA LUCIDUMAbstract
Planterosomal gel exhibit better pharmacokinetic and pharmacodynamic profile than the conventional herbal extracts. The objective of the present research work was to develop, characterize and evaluate the in-vitro antifungal activity of planterosomal gel in comparison to pure plant extract. Planterosomal gel of Ganoderma lucidum was prepared by incorporating gelling agent in planterosomal suspension. Planterosomal gel of G. lucidum was subjected to different evaluation parameters like pH, spreadability, in-vitro release study, ex-vivo permeation study, and in-vitro antifungal activity. Results of in-vitro release studies and ex-vivo skin permeation studies showed that the planterosomal gel releases the active ingredients in a controlled manner and showed higher skin permeability in comparison to G. lucidum gel. The optimized planterosomal gel showed moderate antifungal activity when compared with a standard antifungal agent. So, it was concluded that the planterosomal gel is an advanced form of herbal formulation which enhances the retention time and skin permeability when applied topically.