DEVELOPMENT OF FLURBIPROFEN SODIUM ORAL DISINTEGRATING TABLETS BY DIRECT COMPRESSION AND SUBLIMATION TECHNIQUE

Objective: The present work aimed to prepare flurbiprofen tablets using different concentrations of super disintegrants like croscarmellose sodium, sodium starch glycolate cross povidone sublimating agent thymol. Methods: The tablets were prepared by direct compression and sublimation technique using different concentrations of super disintegrants. The prepared tablets were evaluated for different parameters like hardness, friability, weight variation, thickness, content uniformity, wetting time, disintegration time, and dissolution study. Morphology of pure drug and optimized formulation were revealed by using SEM. Results: All the formulations prepared with the highest concentration of super disintegrant showed the highest drug release. Formulations from F11 to F13 were prepared with the sublimation technique. F11 formulation showed the highest drug release because of its porous nature, which resulted from the sublimation technique. Conclusion: The optimized formulation of the sublimation method (F11) was porous in nature. In-vitro drug release of all formulations prepared with the highest concentration of super disintegrant showed higher drug release than lower concentrations. The formulations prepared by the sublimation technique showed good drug release compared to the direct compression method.