DEVELOPMENT OF HERBAL NIOSOMES FOR WOUND HEALING

Traditionally Psidum guajava has been used for the treatment of several kinds of disorders. The component quercetin a flavonoid that is present in the guava leaves, is responsible of having wound healing properties, so the aim and objective of the study was to Develop Herbal loaded Niosomes for the treatment of Wound Healing. To enhance the transport and efficacy of many materials through stratum corneum one of various methods expanded nowadays is the usage of new drug delivery system such as Niosomal formulations. Niosomes are self assemblies of non ionic surfactants with or without cholesterol, which can be used for both hydrophilic and hydrophobic substances. The extraction of Psidum guajava is performed by Soxhlet apparatus, and the extract is evaluated for phytochemical screening, antimicrobial activity, and TLC. Materials used in the formulation are span 60, cholesterol, diethyl ether, chloroform, buffer and extract. The herbal drug-loaded niosomes are prepared by using reverse phase evaporation method. Total twelve formulations are prepared and the formulations (F1, F2, F3, F4, F5, F6) were prepared by varying drug to surfactant ratio and formulations (F7, F8, F9, F10, F11, F12) were prepared by varying cholesterol ratio. The evolved herbal niosomes are evaluated for drug content, entrapment efficiency, particle size, zeta potential, and in-vitro drug release. The final optimized batch F7 containing span 60, cholesterol of 2:2 ratio showed good drug content of 83.4%, the particle size of 919.5 nm, the zeta potential of -84.1 mV, entrapment efficiency of 90.4%, and in-vitro drug release of 85.32%. The formulation is successfully developed for wound healing.