DEVELOPMENT OF NEW ANALYTICAL METHODS FOR QUANTITATIVE ESTIMATION OF RACECADOTRIL AS AN ACTIVE PHARMACEUTICAL INGREDIEN BY UV SPECTROPHOTOMETERAbstract
A simple and sensitive spectroscopic method was developed for the estimation of Racecadotril in pharmaceutical dosage forms. This method is based on Racecadotril, showing absorbance at 231 nm in methanol. This method obeys Beers law in the concentration range of 8 to100 μg mL-1 respectively. The proposed method is precise, accurate and reproducible and can be extended to the analysis of Racecadotril in bulk and tablet formulations. The method was linear (r=0.9998) at concentrations ranging from 8 to 100 µg ml-1, precise (repeatability and intermediated precision), exact (method of standard addition), and Limit of detection µg ml-1 (0.088749). Limit of quantification µg ml-1 (0.268938) was found and the % recovery is found 99.69%.
Pintoo Tank*, Aarti Zanwar, A.K. Seth and Sharad Kumar
Department of Pharmacy, Sumandeep Vidyapeeth, Vadodara- 391 760, Gujarat, India
24 November, 2011
14 January, 2012
21 March, 2012
01 May, 2012