DEVELOPMENT OF NOVEL CARBOHYDRATE BASED COMPOUNDS FOR BETTER ANTIPYRETIC ACTIVITYAbstract
Carbohydrate-based therapeutics are extremely potent, and many carbohydrate-based drugs are in the stage of preclinical or clinical trials. There is a growing interest in developing carbohydrate analogues for novel drug discovery as most of the recently used carbohydrate drugs display significant pharmacological activities and low toxicity. Also, the search for an antipyretic drug is a never-ending challenge. This research aimed at the development and synthesis of a series of amide-linked sugars (PV1-PV20) by coupling brominated sugars with varying amino acids coupled with nicotinic acid (GP1-GP10). Characterization of the derivatives synthesized was done by Infrared and Nuclear Magnetic Resonance Spectroscopy. These congeners were tested to analyze their antipyretic potential, and eight analogs out of twenty showed significant antipyretic activity. Thus, the carbohydrate-based amide derivatives show important action in obstruction and therapy of fever. Further work on these lines may play an important role in maintaining good health at a low cost.
P. Grover, J. Singh *, L. Mehta, G. Kapoor and K. Nagarajan
Lord Shiva College of Pharmacy, Near Civil Hospital, Sirsa, Haryana, India.
07 July 2020
22 November 2020
06 May 2021
01 July 2021