DEVELOPMENT OF OSMOTICALLY CONTROLLED DRUG DELIVERY SYSTEM OF METFORMIN HYDROCHLORIDEAbstract
The aim of the present study was to formulate an osmotically controlled drug delivery system (O-CDDS) of Metformin hydrochloride to reduce the frequency of multiple dosing in non-insulin dependent diabetes mellitus-II which is a lifelong disease. Metformin hydrochloride a BCS Class-III drug having a poor biological half-life of 6 h. O-CDDS of Metformin hydrochloride is a recent approach for the zero-order release profile. Different factors X1 (effect of percentage of plasticizer), X2 (effect of percentage of release modifier), X3 (effect of percentage of coating) were optimized using central composite design. The granules were prepared by wet granulation technique using PVP K90 as a binding agent. Evaluations of granules like bulk density, tapped density, Hausner’s ratio, carr’s compressibility index, angle of repose was done. Then core tablets were prepared using 16 station tablet press and evaluated for hardness, friability, weight variation. For the preparation of a semi-permeable membrane, the coating of cellulose acetate using polyethylene glycol 400 as a plasticizer was done. Then drilling was done mechanically to create the delivery orifice. Finally, the dissolution was performed and formulation (F-4) was found the best which delivered the drug at zero order. The dissolution data of F-4 was compared with the marketed formulation. This study demonstrated the zero-order release which is independent of pH and hydrodynamics of dissolution.
K. Jangra, R. Verma and D. Kaushik *
Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, Haryana, India.
10 March 2019
26 November 2019
23 December 2019
01 January 2020