DEVELOPMENT OF pH-INDEPENDENT MUCOADHESIVE PELLETS FOR EFFECTIVE TREATMENT OF VAGINAL CANDIDIASISAbstract
Objective: The present investigation aims to develop pH-independent mucoadhesive pellets using the extrusion-spheronization procedure and the inter-polyelectrolyte complex (IPEC) of Chitosan-Carbopol 71G. Miconazole was used as a representative drug in this study. Materials and Method: It was found that the composition of the formulation impacts the extrusion of the prepared dough mass. The generation of pellets within a narrow size range was also studied as a function of spheronization speed and time. The precipitation method was utilized to create IPEC. Compatibility between the drug and the additives was confirmed through FT-IR and DSC testing. Results: The MP3 formulation demonstrated consistent swelling across a wide pH range, without any abrupt alterations in swelling at the pH study points of 4.5 or 7. Evidence from in-vivo X-ray scans indicated that the pellets remained intact in the vaginal canal for an approximate duration of 8 hours. Short-term stability studies of the formulation affirmed its consistency throughout the investigation. Conclusion: The study showed that a Chitosan-Carbopol 71G interpolymer complex can function as a pH-independent drug delivery system for the sustained release of miconazole nitrate. This makes it beneficial for treating candidiasis.
Bandaru Sravani, T. Reshma and Nawaz Mahammed *
Department of Pharmaceutics, Raghavendra Institute of Pharmaceutical Education and Research, K. R. Palli Cross, Anantapur, Chiyyedu, Andhra Pradesh, India.
28 March 2023
18 May 2023
31 May 2023
01 November 2023