DEVELOPMENT OF SUSTAINED RELEASE MATRIX TABLETS OF RAMIPRIL AND EVALUATION OF POLYMER EFFECT ON IN-VITRO RELEASE PATTERNAbstract
The objective of the current study was to design an oral sustained release matrix tablet of Ramipril and to evaluate the effect of polymer on release pattern of the drug. Tablets were prepared by direct compression method using Methocel (Hydroxy Propyl Methyl Cellulose) K100MCR and Methocel (Hydroxy Propyl Methyl Cellulose) K4MCR, as matrix forming polymer. Dissolution studies were carried out in 500 ml phosphate buffer (pH 6.5) for 8 hours. The release mechanism was explored with zero order, first order, Higuchi equation and Korsmeyer’s equation. The drug release followed Higuchi equation. It was found that the release of drug from matrix tablet decrease with the increasing of percentage of polymer. The two high viscosity polymers (Methocel K4MCR and Methocel K100MCR) were found suitable for the study.
Monsur Ahmed, Sayed Koushik Ahamed, Syed Masudur Rahman Dewan, Md. Mizanur Rahman Moghal*
Department of Pharmacy, Noakhali Science and Technology University, Sonapur, Noakhali-3814, Bangladesh
11 November, 2012
17 December, 2012
15 February, 2013
01 March, 2013