DIFFERENT TYPES OF DIAGNOSTIC AND TREATMENT METHODS FOR ACUTE LYMPHOBLASTIC LEUKEMIA AND APPLICATIONS OF EXTRACELLULAR THERAPEUTIC ENZYME L-ASPARAGINASEAbstract
The extracellular L-Asparaginase is an amidase group enzyme. In recent years enzymes gained greater importance in clinical research. The enzyme’s capability to convert L-Asparagine into Aspartic acid and ammonia is the motivation after its anti-cancer action. ALL is a type of hematologic cancer that mainly affects children at the age of 2 to 10 years. L-asparaginase is a basic constituent of ALL and Hodgkin’s lymphoma treatment. Because its foreword into pediatric treatment procedures in the 1960s, continued existence rates in children have steadily increased to almost 90%. Juvenile and adolescent patients diagnosed with ALL at the age group of 15-39 years have historically had poorer outcomes. Different diagnostic methods are available for ALL like blood tests, Bone marrow tests, Imaging tests and Spinal fluid tests. Apart from its medical applications, it is broadly used in the food industry to engage in acrylamide, a probable human carcinogen, and production in carbohydrate-rich foods cooked at high temperatures. L-Asparaginase plays an important role in the biosynthesis of the aspartic family of amino acids. L- Asparaginase has also been used to develop a diagnostic biosensor.
Maram Bhargavi and Ravuri Jaya Madhuri *
Department of Applied Microbiology, Sri Padmavati Mahila Visvavidyalayam, Tirupati, Andhra Pradesh, India.
30 November 2021
12 January 2022
28 January 2022
01 August 2022