DIRECT SPECTROPHOTOMETRIC DETERMINATION OF SATRANIDAZOLEAbstract
A direct spectrophotometric method was developed by the authors for the detection and determination of satranidazole in pure form as well in pharmaceutical formulations in the form of tablets and capsules. The method was based on the formation of a reddish-purple color dye, due to the diazotization reaction between the nitro group of the drug sample, sulphanilamide and NEDA. The drug sample dissolved in hot water, followed by the addition of 2ml each of 0.5% Sulphanilamide and 0.3% NEDA. It exhibited a stable instantaneous reddish purple, colour, which showed maximum absorbance at 540nm. Beer’s law was found to be obeyed in the range 50-300 µgmL-1, with a limit of detection of 0.09 µgmL-1. The method was found to be simple, accurate and rapid.
G.V.S.R. Pavan Kumar*, P.Y. Venkata Rao, B. Krishna Kumar, V. Prasanthi and B. Sreerama Murty
Department of Chemistry, Maharajah’s Post Graduate College, Vizianagaram-535002, Andhra Pradesh, India
17 May, 2012
21 August, 2012
29 August, 2012
01 September, 2012