DISULFIDE BRIDGING: A POTENT STRATEGY FOR ANTI-TUMOR DRUG DELIVERYAbstract
To increase the efficacy of present anti-tumor agents, tumor-targeting can be proved as a successful approach for effective and safer drug delivery with less toxicity. According to researchers, for an effective tumor targeting module, disulfide linkage plays an important role in providing a medium for conjugating an anti-tumor drug with a carrier like vitamins and fatty acids. Disulfide bonds with unique chemical and biophysical properties can be used as cleavable linkers to deliver chemotherapeutic drugs. From the literature review, it has been observed that a disulfide bond acts as a self-immolating linker, which gets cleaved inside the body in the presence of intracellular glutathione; otherwise, it is stable in blood circulation. In this review, we discussed various strategies available in literature using disulfide as a linker in potent tumor targeting agents. Various successful conjugates are described here, which are currently under clinical trials.
Amardeep Kaur, Shikha Dhiman and Manu Sharma *
M. M. College of Pharmacy, M. M. Deemed to be University, Mullana, Haryana, India.
22 July 2021
16 September 2021
24 September 2021
01 May 2022