DNA INTERACTION STUDIES BY UV OF COPPER COMPLEX BASED ON HETEROCYCLIC CHALCONESAbstract
Privileged structures have been widely used as an effective template in medicinal chemistry for drug discovery. Chalcone is a common simple scaffold found in many naturally occurring compounds. Chalcones, considered as the precursors of flavonoids and isoflavonoids, are abundant in edible plants. Chalcone metal complexes and their derivatives have been known over the past fifty years. Copper is an essential element, and hence it is used to synthesize metal complexes. Copper possesses a broad spectrum of activity and a higher DNA binding ability when compared to platinum drugs. The metal-based drugs may range from natural products to artificial organic molecules. Their exceptional magnetic optical radioactive are used in many non-invasive methods like magnetic resonance imaging (MRI), position emission tomography (PET), optical imaging. Copper-based metal complexes have been studied extensively towards DNA interaction aspects. The binding ability of the complexes has been explored based on the results of DNA binding studies assessed by different spectroscopic techniques like UV absorption titration. Thus, we are reporting DNA interaction studies using UV spectroscopic titrations of the copper complex based on heterocyclic chalcones to signify it as an efficient interacting agent.
M. M. Maste *, V. Hegde, S. M. Desai, A. Saxena, P. Inamdar and P. Debnath
Department of Pharmaceutical Chemistry, KLE College of Pharmacy, KLE Academy of Higher Education and Research, Belagavi, Karnataka, India.
09 December 2019
08 April 2020
11 April 2020
01 December 2020