DOCKING STUDIES OF BENZIMIDAZOLE DERIVATIVES USING HEX 8.0Abstract
N-mannich bases of benzimidazole derivatives can work against convulsions. Docking used for virtual screening of database and for the prediction of the strongest binders based on various scoring functions. Docking studies were carried out on different benzimidazole derivaties for better anticonvulsant activity which is important for the development of new class of inhibitors. Protein–ligand interaction plays an important role in structural based drug design. In our research we selected different receptors. The receptors were docked with different imidazole derivatives and the energy values were obtained. Our study reveals that highest minimal energy values were observed with receptors like 4NF8, 4JWY, 4JWX, 3QEK, 3OEK, 3OEL, 3OEM, 3OEN. The results suggests that N-mannich bases of benzimidazole derivatives might be a potential targets of NMDA receptors for effective anticonvulsant activity.
M. Sai Harika *, T. Raj Kumar and L. Siva Sankar Reddy
Department of Pharmaceutical Chemistry, Creative Educational Society’s College of Pharmacy, Chinnatekur, Kurnool, Andhra Pradesh, India.
14 September, 2016
03 December, 2016
16 December, 2016
01 April, 2017