DOES THE WHOLE BODY VIBRATION ALTER THE EFFECT OF A CORIANDRUM SATIVUM EXTRACT ON THE BIODISTRIBUTION OF THE RADIOPHARMACEUTICAL TECHNETIUM-99M SODIUM PERTECHNETATE AND SOME BIOMARKERS IN WISTAR RATS?Abstract
The exposure to vibrations generated in oscillating/vibratory platform produces whole body vibration (WBV) exercises. The effect of the WBV in the concentrations of some biomarkers and his association between some substances has been investigated. Natural products have been used by the humans as food source and as medications. Coriandrum sativum (CS) is used for the treatment of diabetes and gastrointestinal complications. The aim of this study was evaluate if the WBV modify the effect of a CS on the biodistribution of Na99mTcO4 and in some biomarkers in Wistar rats. Rats were divided in: control group (CON) received of 0.9%NaCl solution (saline); treated group with 1.0 mL CS 8g/mL (COR); PLA were submitted to WBV (12 Hz) and also received 1.0 mL of saline; COR + PLA received 1.0 mL CS 8g/mL and were submitted to WBV. Na99mTcO4 was administrated via ocular plexus. After 10 min, sample of blood obtained from by cardiac puncture was used for biochemical analysis and organs isolated to determine %ATI/g. %ATI/g had a significant (p<0.05) alteration in spleen. Related to the biomarkers, significant (p<0.05) alterations were found in concentrations of the cholesterol, triglyceride, alkaline phosphatase, bilirubin and CK. Putting together all the findings reported in this investigation, the results indicated that the treatment with the association of an extract of CS and WBV (12 Hz) could have; (i) effect in the biodistribution of the Na99mTcO4 (ii) action in some organs altering the concentration of some biomarkers.
E.H.F.F. Frederico*, F.S. Carmo, A. Arnóbio, S.S.V. Guedes, D.C. Sá-Caputo, 4, L.C. Bernardo, C.A.S. Guimarães, N.R. Asad and M. Bernardo-Filho
Graduate Program on Clinical and Experimental Physiopathology , Rio de Janeiro State University, Avenida 28 de Setembro, 87, 20551030, Rio de Janeiro, Brazil
10 February, 2014
04 June, 2014
16 July, 2014
01 August, 2014